Tricoaid Science

Hair Growth & Copper Tripeptides

It was discovered that copper peptides stimulated healing of wounds and also increased the size of hair follicles after many years of research. During the second World War, doctors noticed that patients with severe burns or burn scars had a better chance of scar healing if hair follicles began growing at the edges of the burned area. It appeared that new skin cells were arising from the hair follicles and migrating to the surrounding damaged skin and that copper played a role in this process.

Peptides are short polymers formed from the linking of α-amino acids. A tripeptide is a peptide consisting of three amino acids joined by peptide bonds. Some peptides have an affinity for bonding with copper, thus creating a “copper peptide” or a “copper tripeptide”.  

There are many causes of hair loss, the most common are:

  • the production of DHT, which is responsible for male pattern balding
  • progressive shrinking of hair follicles as we age
  • diminished blood supply to the hair follicles
  • stress & hormonal imbalance
  • poor nutrition
  • inflammation around follicles due to autoimmune disorders
  • damage to hair shafts due to hair treatments such as perms & dyeing 

Researchers have determined that the copper solutions applied to the scalp

  • increase follicle size
  • rebuild the blood supply to damaged follicles
  • increase melanin synthesis, necessary to keep hair from turning white
  • increase subcutaneous fat below the scalp which seems to support function for the hair follicle
  • prolong the hair growth phase
  • inhibit the formation of DHT, hence reducing hair loss from male pattern balding in both men and women
  • repair scalp damage
  • reduce inflammation

This all leads to a healthy head of hair.

Ref.

  1. Perez-Meza et al. Int. Journal of Cosmetic Surgery Vol 6 1998, pp 80-4
  2. H Uno, et als. 1995. Journal of Invest. dermatology. 101; 143-147.
  3. Patt, Duncan and Kalis (University of Reims, France)  Dermatological Research Techniques,  (CRC Press), pp-217-226, 1996
  4. Sugimoto et al. Cations inhibit specifically 5 alpha reductase found in human skin. J Invest Dermatol 1995 May: 104(5), 775-8

 

Hair & Glycogen

The growth rate of anagen hair is dependent on the proliferation rate of bulbar matrix cells; the growth rate of these cells depends on the nutrition and energy supply available. Glycogen comes in huge quantity in the cells of the external epithelial sheath of the anagen follicle. The glycogen ensures the intense energy needs of the follicle in active growth. In the same way, an increase of the oxygen consumption comes before the mitotic activity of cells in the hair bulb.

Hair follicles in growth use glycogen, an energy cellular reservoir according to the metabolism ways of Embden Meyerof, Pentose and Kerbs.

Glycogen has a stimulating effect on the growth of hair follicles and on the division of bulbar keratinocytes.


Copper tripeptide complexes are known to stimulate the formation of new blood vessels and inhibit action of 5 a-Reductase, the enzyme that reduces testosterone to DHT.
Glycogen ensures the intense energy needs of the follicle in active growth.
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